Etiology analysis and G6PD deficiency for term infants with jaundice in Yangjiang of western Guangdong

Objective Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim this study is to evaluate factors associated with hyperbilirubinemia in infants from western part Guangdong Province, and assess contribution G6PD jaundice. Methods term People's Hospital Yangjiang June 2018 July 2022 were recruited for retrospective analysis. All underwent quantitative detection enzyme. etiology was determined through laboratory tests clinical manifestations. Results Out 1,119 infants, 435 cases presented For analysis, infection responsible 16.09% (70/435), accounted 9.66% (42/435), which 3 complicated acute bilirubin encephalopathy), bleeding 8.05% (35/435), hemolytic diseases 3.45% (15/435), breast milk jaundice 2.53% (11/435). One case (0.23%) attributed congenital hypothyroidism, multiple etiologies 22.3% (97/435), 35.63% (155/435) unknown etiology. Of jaundiced 19.54% (85/435) had deficiency, while only 10.23% (70/684) non-jaundiced deficiency; difference found be statistically significant ( P < 0.001). Furthermore, hemoglobin levels (146.85 ± 24.88 g/L) lower than those without (156.30 22.07 = 65 mutation testing, six different genotypes identified, including c.95A > G, c.392G T, c.1024C c.1311C c.1376G c.1388G A, c.871G A/c.1311C T/c.1388G T/c.1311C T.65iciency Conclusion In newborns Yangjiang, infection, disease identified as main causes encephalopathy. Specifically, Hemolytic may lead reduced increased infants.